GLP receptors, short for Glucagon-Like Peptide receptors, are a type of receptor found in the body, primarily in the pancreas, gastrointestinal tract, brain, heart, and kidneys. These receptors are activated by glucagon-like peptide hormones, specifically GLP-1 and GLP-2, which are released from the intestines in response to food intake.
GLP-1 receptors play a crucial role in regulating blood sugar levels by stimulating insulin secretion from pancreatic beta cells, suppressing glucagon secretion from pancreatic alpha cells, slowing down gastric emptying, and promoting satiety. These actions help in controlling postprandial (after meal) glucose excursions and contribute to overall glucose homeostasis.
Also found in the brain! GLP-1 receptors are also found in the brain, where they regulate appetite and food intake. Activation of GLP-1 receptors in the brain induces a feeling of fullness or satiety, which can help in controlling body weight. 👏🏼
Due to their role in glucose metabolism and help with the food noise, Medications like Mounjaro (known as GLP-1 receptor agonists), which mimic the action of GLP-1, are used to lower blood sugar levels and promote weight loss in individuals with type 2 diabetes. Yah!
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